Disc degeneration remains a key cause of chronic low back pain and the pain often persists despite surgery. NIH-funded basic science and preclinical studies are investigating molecular-level mechanisms that cause discs in the spine to degenerate, as well as protective mechanisms involved in disc remodeling that may diminish with advancing age. Such studies may help identify future therapeutic strategies to block degenerative mechanisms or promote remodeling processes. NIH also is funding early research on stem cell approaches to promote disc regeneration and rejuvenate cells of the nucleus pulposus, the jelly-like substance in the center of intervertebral discs that loses water content as people age.

If low back pain occurs after a recent injury — such as a car accident, a fall or sports injury — call your primary-care physician immediately. If there are any neurological symptoms, seek medical care immediately. If there are no neurological problems (i.e. numbness, weakness, bowel and bladder dysfunction), the patient may benefit by beginning conservative treatment at home for two to three days. The patient may take anti-inflammatory medications such as aspirin or ibuprofen and restrict strenuous activities for a few days.
The hip flexors play an important role in everyday mobility and exercise. Involved in pulling the knee toward the hip, most movements either directly or indirectly use the hip flexors. That’s why even the slightest injury can cause great discomfort. Learn how you can recover from a hip flexor injury, and what precautions can be taken to avoid them.
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